Spalt-like transcription factor 1 (SALL1)

Spalt-like transcription factor 1 is a member of the SALL family of zinc finger transcription factors, distinct for its DNA-binding specificity toward A/T-rich sequences via C-terminal and double zinc finger domains. It localizes to heterochromatin, orchestrates gene repression, and is required for normal development, particularly of the kidney and other organs. Mutations in SALL1 cause Townes-Brocks syndrome, manifesting as multisystem developmental defects. SALL1 is implicated in chromatin remodeling, likely through interactions with the NuRD histone deacetylase complex, and regulates STEM cell and microglia identity by fine-tuning chromatin accessibility and transcriptional programs.

Other names

Sal-like protein 1SAL1ZNF794HSal1Sal-1HSAL1TBSZinc finger protein 794Zinc finger protein SALL1Zinc finger protein Spalt-1HEL-S-89epididymis secretory protein Li 89

No approved drugs or tool compounds directly targeting SALL1. Mechanistic studies focus on loss- or gain-of-function interventions in model systems for disease modeling or cellular identity.