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Target intelligence / Profile preview
Spalt like transcription factor 4 pseudogene 5 (SALL4P5)
- Target
- SALL4P5
- Molecular classification
- Pseudogene, Noncoding RNA (ncRNA)
01
Overview
SALL4P5 is a noncoding pseudogene transcript homologous to the protein-coding SALL4 gene. Unlike most pseudogenes considered nonfunctional, SALL4P5 regulates SALL4, an established oncogene in hepatocellular carcinoma, by interacting with the DNA methyltransferase DNMT1—resulting in locus-specific demethylation and activation of SALL4 transcription. SALL4P5 upregulation occurs in hepatitis B virus–related HCC before SALL4 induction, suggesting a role in early cancer development. Its biological activity is epigenetic, with primary nuclear localization, and it has demonstrated effects on cellular proliferation and migration via SALL4 regulation, but is not a direct pharmacological target as a receptor, enzyme, or transporter[1][3].
- Other names
- SALL4P5Sal-like 4 pseudogene 5SALL4 pseudogene 5
02
Biological functions
Epigenetic regulation (DNA demethylation of oncogene regulatory regions via DNMT1 interaction)Indirect activation of oncogene expression (upregulation of SALL4)Regulation of cell proliferation and migration (through SALL4 upregulation)
03
Disease associations
Cancer (specifically hepatocellular carcinoma)Potential involvement in other cancer types (via regulation of SALL4)
04
Biomarkers
SALL4P5 expression (may predict or correlate with SALL4 activation and HCC progression; possible prognostic biomarker use)
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