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Target intelligence / Profile preview
SPARC antisense RNA 1 (SPARC-AS1)
- Target
- SPARC-AS1
- Molecular classification
- Long non-coding RNA, Other
01
Overview
SPARC antisense RNA 1 (SPARC-AS1), also known as CLMAT3 (Colorectal liver metastasis associated transcript 3), is a long non-coding RNA (lncRNA) implicated in the progression and metastasis of colorectal cancer. High expression levels of SPARC-AS1 in colorectal cancer (CRC) are significantly associated with aggressive tumor phenotypes, poor patient prognosis, and liver metastasis. Mechanistically, SPARC-AS1 interacts with chromatin remodeling factors and may help regulate genes related to metastasis, such as MMP9, often through epigenetic mechanisms. Its function is not fully understood but accumulating evidence points to its role as a regulatory molecule contributing to CRC tumorigenesis and metastatic spread[1][2].
- Other names
- CLMAT3Colorectal liver metastasis associated transcript 3CTB-113P19.1
02
Biological functions
Regulation of chromatin remodelingPromotion of cell proliferationPromotion of cell migrationPromotion of metastasis
03
Disease associations
CancerColorectal cancerMetastasisLiver metastasis
04
Biomarkers
Potential prognostic biomarker for aggressive colorectal cancer and poor prognosis[1]
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