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Target intelligence / Profile preview
SPARC-related modular calcium binding protein 2 (SMOC2)
- Target
- SMOC2
- Molecular classification
- Matricellular protein, Glycoprotein, Extracellular matrix protein, Calcium-binding protein
01
Overview
SMOC2 is a secreted matricellular glycoprotein that belongs to the SPARC family. It plays a crucial role in promoting matrix assembly, endothelial cell proliferation, and angiogenesis. SMOC2 contains structural domains such as Kazal, thyroglobulin-like, and EF-hand calcium-binding domains. It is involved in various biological processes, including embryogenesis and wound healing, and its dysregulation has been associated with dental developmental defects and autoimmune conditions like vitiligo.
- Other names
- MSTP117BA37D8.1MST117DJ421D16.1MSTP140DTDP1BA270C4A.1
02
Mechanism of action
SMOC2's primary mechanism involves promoting matrix assembly and modulating cellular responses to angiogenic growth factors. It synergizes with factors like vascular endothelial growth factor and basic fibroblast growth factor to enhance angiogenesis.
03
Biological functions
Cell proliferationAngiogenesisEndothelial cell migrationMatrix assemblyCell adhesivenessOdontogenesis
04
Disease associations
Dental developmental defects (e.g., dentin dysplasia)VitiligoTumor growthMyocardial ischemia
05
Safety considerations
Variations or mutations in SMOC2 have been linked to severe dental malformations and other developmental issues, implying potential risks if it were targeted therapeutically.
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