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SPART antisense RNA 1 (SPART-AS1)
- Target
- SPART-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA
01
Overview
SPART antisense RNA 1 (SPART-AS1) is a long non-coding antisense transcript situated on chromosome 13q13.3; this RNA is presumed to act primarily at the RNA level, regulating the expression of its sense-strand counterpart, the SPART (SPG20) gene, through mechanisms common to antisense RNAs such as transcriptional interference and chromatin modification. While antisense RNAs often modulate gene expression with regulatory effects in cis or trans, specific disease roles or direct clinical applications for SPART-AS1 have not been established. SPART-AS1 is not considered a therapeutic target such as a receptor, enzyme, transporter, or transcription factor; rather, it is classified as a regulatory non-coding RNA[1][2][4][9][10].
- Other names
- C13orf43SPG20-AS1SPG20OSSPG20 opposite strand transcript proteinSPG20 opposite strandSPART antisense RNA 1
02
Biological functions
Regulation of gene expression (antisense regulation of SPART/SPG20), likely via transcriptional interference, chromatin modification, and promoter/enhancer interaction
03
Disease associations
Other (disease role not clearly established for SPART-AS1 itself; SPART/SPG20 mutations are linked to Troyer syndrome, but SPART-AS1’s direct disease association remains uncharacterized)
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