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Spartin (SPART)
- Target
- SPART
- Molecular classification
- Other (cytosolic protein, not a receptor, enzyme, ion channel, or transporter)
01
Overview
Spartin is a cytosolic protein encoded by the *SPART* gene, with important roles in cellular morphology, membrane trafficking, and lipid droplet regulation. Deficiency or mutation of Spartin causes Troyer syndrome (hereditary spastic paraplegia 20, SPG20), a neurodegenerative disorder characterized by progressive spasticity, distal muscle weakness, and cognitive disability. Spartin interacts with a variety of intracellular partners involved in the endosomal system and cytoskeletal organization. The protein's name is sometimes confused with computational frameworks such as "SPaRTAN," but these are unrelated to the biological Spartin protein. Spartin is not used as a drug target nor is it commonly assayed as a biomarker.
- Other names
- SPARTSpartinSPG20KIAA0610TAHCCCP1Spastic paraplegia 20 proteinTroyer syndrome proteinTrans-activated by hepatitis C virus core protein 1
02
Biological functions
Endosomal traffickingMicrotubule regulationCellular morphology maintenanceLipid droplet turnoverSignal transduction (minor, associated with disease processes)
03
Disease associations
Neurodegenerative disease (specifically involved in hereditary spastic paraplegia, Troyer syndrome)Other (associated with cellular changes in hepatocyte carcinoma and viral host responses)
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