SPATA31 subfamily D member 1 pseudogene (ENSG00000273597)

SPATA31 subfamily D member 1 pseudogene (LOC100420114, ENSG00000273597) is a processed pseudogene, a segment of the human genome that resembles the functional SPATA31D1 gene. Unlike its parent gene—SPATA31D1, which is thought to play a role in spermatogenesis and cell differentiation[5]—the pseudogene does not encode a functional protein and is considered biologically inactive[1][4]. Processed pseudogenes arise via retrotransposition, where mRNA is reverse-transcribed and inserted into the genome, usually lacking regulatory promoters, often containing mutations and truncations, making them nonfunctional from the outset[4][6]. No evidence supports its direct involvement in disease, drug responsiveness, protein function, or clinical relevance. It is most accurately described as a genomic relic without current biological or clinical utility[1][4][6]. While some pseudogenes can gain regulatory functions or act as decoys for microRNAs, facilitating fine-tuning of gene expression[4], there is no established regulatory or functional activity for this pseudogene. It is important to distinguish this pseudogene from its parent SPATA31D1 (protein-coding gene), which may play a biological role[5].

Other names

LOC100420114Family with sequence similarity 75, member D1 pseudogeneSPATA31D1PFAM75D1PRP11-392A14.9

Not applicable (not a functional gene; no drug mechanism of action applicable)