SPECC1L-ADORA2A readthrough transcript (SPECC1L-ADORA2A)

The SPECC1L-ADORA2A readthrough is a naturally occurring non-coding RNA transcript generated by readthrough transcription between the adjacent SPECC1L and ADORA2A genes on chromosome 22. This chimeric transcript is a candidate for nonsense-mediated decay and is not believed to produce any functional protein. There are no known biological functions, disease roles, or pharmacological targets associated with the SPECC1L-ADORA2A transcript itself. It is not considered a therapeutic target or a receptor, enzyme, transporter, or other protein product[1][3].\n\n**Note**: The individual genes involved in the readthrough—**SPECC1L** (a cytoskeletal protein involved in cell adhesion and migration) and **ADORA2A** (a G protein–coupled adenosine receptor gene)—have biological significance. However, this specific readthrough does not encode a functional molecule and is not a therapeutic target[1][3].\n\n**Summary of error**: SPECC1L-ADORA2A is not a canonical protein target but instead a non-coding readthrough transcript, so should not be annotated as a therapeutic or functional biomolecular target[1][3].

Other names

SPECC1L-ADORA2A