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Target intelligence / Profile preview
Hyaluronidase PH20 (PH20)
- Target
- PH20
- Molecular classification
- Enzyme, Hyaluronidase, Glycosyl hydrolase
01
Overview
Hyaluronidase PH20 (SPAM1, HYAL5) is a GPI-anchored enzyme that degrades hyaluronic acid, a major component of the extracellular matrix. It is crucial for sperm penetration through the cumulus cell layer during fertilization. Recombinant human PH20 (rHuPH20) is used clinically to enhance subcutaneous drug delivery by increasing tissue permeability. Elevated expression has also been observed in demyelinating lesions, suggesting a role in nervous system pathology.
- Other names
- SPAM1HYAL5Sperm Adhesion Molecule 1
02
Mechanism of action
Hydrolyzes hyaluronic acid, reducing viscosity and increasing tissue permeability.
03
Biological functions
Hyaluronic acid degradationExtracellular matrix remodelingSperm penetration of cumulus oophorusFertilization
04
Disease associations
InfertilityDemyelinationNeurological disorders
05
Safety considerations
Anti-drug antibody formationPotential impact on fertility and fetal development (though studies show favorable safety profiles)
06
Interacting drugs
Recombinant human hyaluronidase PH20 (rHuPH20)
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