Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
CD52g
- Molecular classification
- GPI-anchored protein, Glycoprotein
01
Overview
CD52g is a glycoform of the CD52 molecule specifically expressed in the male reproductive tract and abundantly present on the surface of mature human sperm cells. Its unique glycan structure serves as an epitope for certain monoclonal antibodies and is involved in semen clot formation/liquefaction and protection from complement-mediated lysis. It is a target for immunocontraceptive strategies.
- Other names
- SAGA-1Sperm Agglutination Antigen-1Male reproductive tract-CD52
02
Mechanism of action
Monoclonal antibodies targeting CD52g cause sperm agglutination and immobilization, preventing fertilization.
03
Biological functions
Semen coagulationSemen liquefactionProtection from complement-mediated lysisCell surface antigen
04
Disease associations
InfertilityTarget for immunocontraception
05
Safety considerations
Potential for off-target effects in other tissues expressing CD52.Risk of inducing systemic immune responses.
06
Biomarkers
Sperm agglutinationSperm immobilization
Beyond the preview
Go deeper on CD52g.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on CD52g.