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Target intelligence / Profile preview
Sperm equatorial segment protein 1 (SPESP1)
- Target
- SPESP1
- Molecular classification
- Other (acrosomal matrix protein, membrane protein)
01
Overview
Sperm equatorial segment protein 1 (SPESP1) is a protein highly expressed in the testis, primarily localized to the acrosome of postmeiotic spermatids and mature sperm, and concentrated in the equatorial segment of mature sperm. It is a membrane-associated protein essential for the fusion of sperm and egg plasma membranes during fertilization. SPESP1-deficient male mice exhibit significantly reduced fertility due to impaired sperm migration, decreased sperm-egg fusion, and abnormal distribution of acrosomal proteins. SPESP1 serves as an alloantigen in humans and plays a crucial role in the fertilization process. It is not currently considered a therapeutic target, and there are no known drugs that interact with it[1][2][4][5][6].
- Other names
- SP-ESPESPEquatorial segment proteinGlycosylated 38 kDa sperm protein C-7/8UNQ732/PRO1418
02
Biological functions
Sperm-egg bindingSperm-egg fusionMale fertility
03
Disease associations
Infertility (male factor)
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