Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Sperm flagellar protein 1 (SPEF1)
- Target
- SPEF1
- Molecular classification
- Other (Microtubule-associated protein), Actin-binding protein
01
Overview
Sperm flagellar protein 1 (SPEF1) is a microtubule-associated and actin-binding protein that promotes the stabilization and bundling of microtubules, especially along the axis of migrating cells, and is essential for the formation and function of ciliary central apparatus. It contributes to cell migration via filopodium and lamellipodium assembly, regulates planar cell polarity, and is critical for ciliary localization of key proteins such as HYDIN and SPAG6. Mutations in SPEF1 have been associated with ciliary motility defects, such as primary ciliary dyskinesia, but it is not currently considered a direct therapeutic target, receptor, enzyme, transporter, or transcription factor in pharmacology
- Other names
- C20orf28SPEF1ACLAMPDKFZP434I114calponin-homology and microtubule-associated protein
02
Biological functions
Microtubule stabilizationPromotion of microtubule bundlingActin bindingFilopodium assemblyLamellipodium assemblyCiliary central apparatus formationRegulation of planar cell polarity
03
Disease associations
Primary ciliary dyskinesiaOther ciliopathies
Beyond the preview
Go deeper on Sperm flagellar protein 1 (SPEF1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Sperm flagellar protein 1 (SPEF1).