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Target intelligence / Profile preview
Sperm microtubule associated protein 2 (SPMAP2)
- Target
- SPMAP2
- Molecular classification
- Other (testis-specific protein, microtubule-associated protein; not a GPCR, ion channel, enzyme, transporter, receptor, or transcription factor)
01
Overview
Sperm microtubule associated protein 2 (SPMAP2) is a testis-specific, microtubule-associated protein encoded by the SPMAP2 gene (HGNC:13706), expressed primarily in the nuclei of haploid male germ cells, particularly during spermatogenesis[1][4][7][8]. Its biological role appears to involve protein assembly, possibly through interactions with T-complex protein 1 subunit epsilon and other components integral to sperm formation and maturation[4]. Alternative splicing results in multiple isoforms, and the gene is evolutionarily conserved in mammals, but is not widely expressed outside of male germ cells[3][4][7]. Although sometimes classified among "cancer/testis antigens" due to its restricted expression, there are currently no known drugs, diagnostic biomarkers, or recognized safety issues directly linked to this protein, and no evidence supporting its direct involvement in common disease processes other than marginal literature mentions in axonal neuropathies[4].
- Other names
- CT56THEGTHEG1Cancer/testis antigen 56Testicular haploid expressed gene proteinTheg homologTestis-specificTHEG spermatid protein
02
Mechanism of action
None known. No drugs or modulators with described mechanisms regarding SPMAP2
03
Biological functions
SpermatogenesisProtein assembly in male germ cellsMicrotubule associationHaploid germ cell nuclear function
04
Disease associations
Other: One association with "Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 3" (uncertain functional relevance, not a well-established disease marker)
05
Safety considerations
None reported, as no therapeutics target SPMAP2
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