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Target intelligence / Profile preview
Sperm microtubule associated protein 2-like (SPMAP2L)
- Target
- SPMAP2L
- Molecular classification
- Other (testis/sperm-associated protein, not a receptor, enzyme, transporter, GPCR, etc.)
01
Overview
Sperm microtubule associated protein 2-like (SPMAP2L) is a protein-coding gene highly expressed in the testis, particularly in late spermatids, where its exact function remains unknown. It is classified as a testis/sperm-associated protein, not as an enzyme, receptor, transporter, or GPCR. SPMAP2L is related to spermatogenesis and may be involved in protein assembly, largely inferred by analogy with its paralog SPMAP2. There is currently no experimental evidence for a direct functional role or disease involvement of SPMAP2L in humans, nor is it a known therapeutic target. The protein is alternatively spliced and has several isoforms, but its specific clinical significance and mechanism remain unclear.
- Other names
- THEGLTesticular haploid expressed gene protein-likeTheg spermatid-like proteintheg spermatid protein likeSperm microtubule associated protein 2 liketesticular haploid expressed gene protein-like
02
Mechanism of action
Not applicable (no known drugs or inhibitors)
03
Biological functions
May play a role in spermatogenesisPossibly involved in protein assembly through interactions with T-complex protein 1 subunit epsilon (inferred from paralog SPMAP2)Precise biological function is unknown
04
Disease associations
Other (no strong direct disease association; diseases associated with the paralog SPMAP2 include spinocerebellar ataxia and SPMAP2L is weakly associated with facioscapulohumeral muscular dystrophy 2, digenic)
05
Safety considerations
None reported
06
Interacting drugs
None known
07
Biomarkers
None known
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