Sperm microtubule inner protein 10 (SPMIP10)

Sperm microtubule inner protein 10 (SPMIP10) is a cytoskeletal-associated protein predominantly found in the microtubule doublets of sperm flagella, where it serves as part of the microtubule inner proteins (MIPs) crucial for the structural integrity and function of the axoneme[1][4][5]. SPMIP10 is essential for maintaining proper sperm motility, presumably by reinforcing and stabilizing the microtubule structure within the flagella[5]. The gene is highly expressed in testis and to a much lower extent in other tissues[2]. Mice lacking SPMIP10 exhibit reduced sperm motility while maintaining normal fertility[3]. While it is not classified as a receptor, enzyme, or classic drug target, its dysfunction may be associated with male infertility related to defects in sperm motility[1][3][5].

Other names

Testis-expressed protein 43C5orf48TEX43Tseg7Sperm-associated microtubule inner protein 10Sperm associated microtubule inner protein 10Testis specific expressed gene 7Testis-expressed sequence 43 proteinMGC163367MGC163369FLJ27505