Sperm microtubule inner protein 2 (SPMIP2)

Sperm microtubule inner protein 2 (SPMIP2) is a structural protein encoded by the SPMIP2 gene (also known as C4orf45) located on human chromosome 4[2]. It is one of a family of microtubule inner proteins (MIPs) involved in reinforcing the structural architecture of the sperm flagellar axoneme. MIPs, including SPMIP2, help form the core of the axonemal doublet microtubules essential for sperm motility[1]. They promote axonemal microtubule stability and integrity, which is crucial for the propulsion mechanisms underpinning male fertility. While the function of SPMIP2 is structural rather than enzymatic or receptor-mediated, defects in similar proteins can be implicated in flagellar malfunctions and potentially contribute to male infertility syndromes[1]. However, there is currently no direct evidence linking SPMIP2 to specific diseases or therapeutic interventions. SPMIP2 is a poorly characterized flagellar structural component. It is not a receptor, enzyme, channel, or transcription factor. Its main biological function is supporting the physical stability of the sperm flagellum; it does not initiate signal transduction or mediate recognized disease mechanisms[1][2].

Other names

C4orf45FLJ25371ENSG00000164123Sperm-associated microtubule inner protein 2protein SPMIP2sperm associated microtubule inner protein 2uncharacterized protein C4orf45