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Sperm microtubule inner protein 4 (SPMIP4)
- Target
- SPMIP4
- Molecular classification
- Microtubule inner protein (MIP), Structural protein, Other (axonemal structural protein)
01
Overview
Sperm microtubule inner protein 4 (SPMIP4) is a protein localized to the centrosome and sperm flagella, where it forms part of the microtubule inner proteins (MIPs) embedded in dynein-decorated doublet microtubules (DMTs)[2][4][6][8]. SPMIP4 acts to reinforce and stabilize the microtubule structure, supporting the mechanical integrity necessary for sperm flagellar beating and motility[1][2][8]. It is critical for maintaining the axonemal architecture required for effective sperm movement but is not known to be involved in signal transduction, metabolic regulation, or any pathway currently exploited by therapeutic drugs[2][4][8][11]. There is no evidence directly linking SPMIP4 to disease, nor is it a target for pharmacological intervention.
- Other names
- Sperm-associated microtubule inner protein 4SPMIP4C7orf31Uncharacterized protein C7orf31
02
Biological functions
Microtubule stabilization in sperm flagellaMaintenance of sperm motilityStructural reinforcement of axonemal doublet microtubules
03
Disease associations
Other (potential role in male infertility linked to sperm motility, but no direct association with specific diseases is documented)
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