Sperm microtubule inner protein 5 (SPMIP5)

Sperm microtubule inner protein 5 (SPMIP5) is a protein localized to the cytoskeleton and specifically the axonemal A tubule inner sheath of the sperm flagellum, where it is part of the microtubule inner protein (MIP) complex associated with dynein-decorated doublet microtubules[1]. It is predicted to function by reinforcing and stabilizing the structure of microtubules in sperm flagella, thus playing a role in flagellated sperm motility[1]. No specific role in disease or drug targeting has been described, and its only established function is in male gamete physiology. The SPMIP5 gene is cataloged as a protein coding gene with identifiers including HGNC: 28500, NCBI Gene: 143379, and UniProtKB: Q8WW14[1][5]. SPMIP5 is predicted to be present in various cellular components involved in flagellar movement, including the cytoskeleton, motile cilium, axonemal A tubule inner sheath, and the sperm flagellum itself[1]. No current evidence supports a role for SPMIP5 as a therapeutic target, no clinical biomarkers, or relevant safety concerns are described in the scientific literature as of September 2025[1][5].

Other names

Sperm-associated microtubule inner protein 5SPMIP5C10orf82MGC33547Em:AC016825.4Uncharacterized protein C10orf82

Not applicable (no therapeutic modulators known)