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Target intelligence / Profile preview
Sperm-tail PG-rich repeat containing protein 4 (STPG4)
- Target
- STPG4
- Molecular classification
- Other (chromatin-associated protein)
01
Overview
Sperm-tail PG-rich repeat containing protein 4 (STPG4), previously known as C2orf61, is a protein predicted to be involved in chromatin binding and histone binding, with a specialized role in the epigenetic reprogramming of the paternal genome after fertilization. It specifically contributes to the conversion of 5-methylcytosine to 5-hydroxymethylcytosine in zygotes, influencing DNA demethylation dynamics in the male pronucleus[2][13][4]. STPG4 is also implicated in protein localization within sperm tail structures and may play a role in the regulation of sperm motility and fertility, though direct functional and disease links in humans are not fully described[1][5]. STPG4 is not currently recognized as a therapeutic target, there are no known interacting drugs, and it is not established as a diagnostic or predictive biomarker.
- Other names
- C2orf61FLJ40172Gonad-specific expression gene proteinSperm-tail PG-rich repeat-containing protein 4uncharacterized protein C2orf61protein STPG4gonad-specific expression gene proteinGSE
02
Biological functions
Epigenetic chromatin reprogrammingregulation of DNA demethylation (5-methylcytosine to 5-hydroxymethylcytosine)chromatin bindinghistone bindingputative role in sperm tail structure and spermatogenesis
03
Disease associations
Other (the gene is associated with male pronucleus development and predicted links to Thelaziasis, but not with major disease areas like cancer or neurodegeneration)
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