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Spermatid maturation protein 1 (SPEM1)
- Target
- SPEM1
- Molecular classification
- Other (testis-specific scaffold/adaptor protein; not an enzyme, receptor, transporter, or transcription factor)
01
Overview
Spermatid maturation protein 1 (SPEM1) is a testis-specific protein encoded by the SPEM1 gene (also known as C17orf83), expressed exclusively in the cytoplasm of developing spermatids during late spermiogenesis[1][3]. It lacks known enzymatic or functional domains and serves as a critical scaffold or adaptor protein, essential for the proper removal of cytoplasm from elongating spermatids. SPEM1 is involved in organizing cytoskeletal and ubiquitin-proteasome system proteins via direct interactions (notably with UBQLN1) at the manchette (a microtubule-based structure) in elongating spermatids[1]. Mice deficient in SPEM1 exhibit complete male infertility due to severe sperm head and cytoplasmic deformities, underscoring its unique and essential role in sperm morphogenesis. There are no reported drugs or established clinical biomarkers targeting SPEM1, and it is not considered a therapeutic target in current medical practice[1][3].
- Other names
- C17orf83FLJ40081Spermatid maturation 1SPEM1spermatid maturation protein 1
02
Biological functions
Spermiogenesis (final stage of sperm maturation)Cytoplasm removal during spermatid maturation
03
Disease associations
Male infertility (due to essential role in sperm morphogenesis and maturation)
04
Safety considerations
Potential infertility risk if gene or protein is disrupted
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