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Spermatid perinuclear RNA-binding protein (STRBP)
- Target
- STRBP
- Molecular classification
- RNA-binding protein, Double-stranded DNA/RNA binding protein, Other (Developmental protein, per Gene Ontology)
01
Overview
Spermatid perinuclear RNA-binding protein is coded by the *STRBP* gene on human chromosome 9. It is an RNA- and DNA-binding protein essential for spermatogenesis, influencing cell differentiation and growth within male germ cells. STRBP binds double-stranded DNA and RNA with a preference for poly(I:C) RNA, and also interacts with single-stranded poly(G) RNA and PRM1 mRNA[1][5][7]. It is predominantly localized in the nucleus and is functionally involved in cellular motility and mechanosensory behavior in germ cells. Disease associations are primarily related to hematologic cancers and cryptorchidism, but STRBP is not established as a direct drug target or biomarker[1][2][5][7].
- Other names
- STRBPSPNRFLJ11307HEL162ILF3Lp74epididymis luminal protein 162epididymis secretory sperm binding protein
02
Mechanism of action
Not applicable; no known drugs or inhibitors target this molecule directly
03
Biological functions
SpermatogenesisCell differentiationRegulation of cell growthRNA bindingDNA bindingCell motilityMechanosensory behavior
04
Disease associations
Hematologic cancerCryptorchidismOther; limited disease associations, mainly developmental/germ cell pathologies
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