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Target intelligence / Profile preview
Spermatogenesis-associated protein 16 (SPATA16)
- Target
- SPATA16
- Molecular classification
- Other (tetratricopeptide repeat-like superfamily), Vesicular transport protein
01
Overview
Spermatogenesis-associated protein 16 (SPATA16) is a testis-specific protein localized to the Golgi apparatus that is essential for spermiogenesis and male fertility. It plays a critical role in the formation of the sperm acrosome during spermatogenesis. Dysfunction or altered regulation (e.g., hypermethylation of its promoter) is associated with male infertility conditions such as oligozoospermia and globozoospermia[1][2][3][4].
- Other names
- NYD-SP12Testis development protein NYD-SP12SPGF6testicular tissue protein Li 185testis-specific Golgi protein
02
Biological functions
Acrosome formationSpermatogenesisSpermiogenesisMale fertility
03
Disease associations
Male infertilitySpermatogenic Failure 6Globozoospermia
04
Biomarkers
Hypermethylation and downregulation correlated with male infertility[1]
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