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Target intelligence / Profile preview
Spermatogenesis-associated protein 17 (SPATA17)
- Target
- SPATA17
- Molecular classification
- Other (Protein, not currently categorized under common drug-target classes such as receptor, enzyme, transporter, or ion channel)
01
Overview
Spermatogenesis-associated protein 17 (SPATA17) is a protein primarily expressed in the testis and is predicted to be involved in the establishment of meiotic spindle localization, mitotic cell cycle, and spindle organization. It is thought to play a critical role in human spermatogenesis, particularly during meiosis, through functions such as calmodulin binding. There are no established drugs that target SPATA17, and it is not currently considered a classic therapeutic target such as a receptor, enzyme, or transporter. There is some evidence for association with biliary cirrhosis and possible male infertility, but no well-established role as a disease biomarker or safety concern in therapeutic development.
- Other names
- IQ motif containing HIQCHMOT17FAP305CFAP305MSRG-11MSRG11spermatogenesis-related protein 11
02
Biological functions
Meiotic spindle localizationMitotic cell cycle regulationSpindle organizationCalmodulin bindingSpermatogenesis
03
Disease associations
Biliary cirrhosis, primary (type 5 and type 3)Possible association with male infertility via impaired spermatogenesis
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