Spermatogenesis-associated protein 22 (SPATA22)

Spermatogenesis-associated protein 22 (SPATA22) is a meiosis-specific protein essential for meiotic recombination, synapsis, and DNA double-strand break repair during meiosis I in germ cells[1][2]. SPATA22 localizes to recombination foci in prophase I, interacting with key meiotic proteins such as MEIOB and RPA, and is required for the progression of meiosis in both males and females. Mutations in the SPATA22 gene cause meiotic arrest at prophase I, resulting in infertility due to failure of gamete production in both sexes[1][4]. In humans, defects are associated with syndromes such as Premature Ovarian Failure 25 and Spermatogenic Failure 96[2]. No small-molecule drugs are known to directly target SPATA22, and it is not considered a current pharmacological target.

Other names

SPATA22NYD-SP20Testis development protein NYD-SP20NYDSP20POF25SPGF96spermatogenesis-associated protein 22testicular tissue protein Li 186