Spermatogenesis-associated protein 25 (SPATA25)

Spermatogenesis-associated protein 25 (SPATA25) is a testis-expressed protein believed to play a role in spermatogenesis. It is encoded by the SPATA25 gene, with documented expression in round spermatids and a postnatal expression pattern that increases in rodent models from day 15 to adulthood[5]. The protein is predicted to be membrane-associated but its molecular classification does not match typical drug or therapeutic target classes such as receptor, transporter, or enzyme[1][3][5][9]. SPATA25 has been genetically linked to male infertility syndromes such as azoospermia, though functional and mechanistic insights are limited. No drugs, biomarkers, or therapeutic interventions are currently associated with SPATA25—indicating its principal relevance is in basic research or as a genetic marker rather than a clinical target[1][3][5][9].

Other names

SPATA25C20orf165TSG23dJ337O18.8Testis-specific gene 23 protein