Spermatogenesis-associated protein 31A1 (SPATA31A1)

Spermatogenesis-associated protein 31A1 (SPATA31A1) is a protein coding gene located on chromosome 9, highly expressed in testis, and believed to play a role in spermatogenesis and cell differentiation. In humans, SPATA31A1 is part of a fast-evolving gene family that expanded its functions to include UV damage sensing and DNA repair, especially in response to environmental stressors such as sunlight exposure. Overexpression of SPATA31A1 in fibroblast cells leads to premature senescence and alters aging-related transcriptional pathways, suggesting a role in cellular and organismal aging. Copy number variation of SPATA31 genes correlates negatively with human longevity, with long-lived individuals having fewer copies. Although associated with certain clinical conditions such as foramen magnum meningioma and Bardet-Biedl Syndrome 15, no direct causative or therapeutic roles have been established. Currently, SPATA31A1 is not considered a druggable target nor associated with approved pharmacological interventions.

Other names

SPATA31A1C9orf36FAM75A1SPATA31A2DKFZP434B204C9orf36AFAM75A2Protein FAM75A1Protein FAM75A2Spermatogenesis-associated protein 31A2SPATA31 subfamily A member 2Family with sequence similarity 75, member A1Family with sequence similarity 75, member A2

None (no drug mechanisms documented for this molecule)