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Target intelligence / Profile preview
Spermatogenesis-associated protein 31A6 (SPATA31A6)
- Target
- SPATA31A6
- Molecular classification
- Other (structural protein involved in spermatogenesis)
01
Overview
Spermatogenesis-associated protein 31A6 (SPATA31A6) is a human protein-coding gene predominantly expressed in the testes, where it may play a role in spermatogenesis, specifically in cell differentiation and actin binding[1][4][5]. It localizes to the acrosomal vesicle and is hypothesized to contribute to processes essential for sperm development, but its exact molecular function in humans remains incompletely characterized[1][4]. Although functional studies are lacking for SPATA31A6 specifically, other closely related SPATA proteins are critical for sperm head development and male fertility in animal models, suggesting potential relevance in human reproductive biology[2]. No evidence supports its classification as a conventional therapeutic target (receptor, enzyme, transporter, etc.), and there is no documentation of drugs, biomarkers, or safety issues associated with this protein[1][4][5].
- Other names
- SPATA31A6FAM75A6Protein FAM75A6OTTHUMG00000013224Family with sequence similarity 75, member A6Spermatogenesis-associated protein 31A6
02
Mechanism of action
None established
03
Biological functions
Cell differentiationSpermatogenesisActin bindingPossibly involved in membrane fusion, DNA replication and repair, microtubule severing, and protein degradation (based on broader family associations)
04
Disease associations
Other (potential role in male infertility, particularly acephalic spermatozoa syndrome, inferred from close orthologs)
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