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Spermatogenesis-associated protein 9 (SPATA9)
- Target
- SPATA9
- Molecular classification
- Other (protein coding gene; no membership in receptor, transporter, enzyme, ion channel, transcription factor, or histone modification families)
01
Overview
Spermatogenesis-associated protein 9 (SPATA9) is a human protein encoded by the SPATA9 gene, primarily expressed in testicular tissue. It is predicted to play a role in testicular development and spermatogenesis, potentially influencing cell differentiation processes critical to the formation and maturation of sperm cells. Dysfunction or alterations in SPATA9 have been associated with male infertility, although its precise molecular functions and mechanisms remain unclear. There is evidence suggesting that the NYD-SP16 protein (a product of SPATA9) functions in the sperm acrosome, contributing to sperm capacitation and the acrosome reaction that is essential for fertilization[2][3][5][7]. No approved drugs are known to interact with SPATA9, and it is not established as a direct therapeutic target.
- Other names
- SPATA9Spermatogenesis associated 9NYD-SP16 protein
02
Biological functions
SpermatogenesisTesticular developmentCell differentiationPossibly acrosome formation and sperm capacitation
03
Disease associations
Male infertilityOther (potentially linked to defects in spermatogenesis)
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