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Target intelligence / Profile preview
Spermatogenic leucine zipper protein 1 (SPZ1)
- Target
- SPZ1
- Molecular classification
- Transcription factor, basic helix-loop-helix-leucine zipper (bHLH-Zip) protein
01
Overview
Spermatogenic leucine zipper protein 1 (SPZ1) is a testis-specific transcription factor characterized by a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain. It is implicated in the regulation of cell proliferation and differentiation during spermatogenesis, functioning within the MAPK signaling pathway. Aberrant overexpression in transgenic models leads to disrupted tissue homeostasis, germ cell apoptosis, and male infertility. In addition, SPZ1 has been associated with tumorigenesis and may serve as a target for Ras-induced cancer therapy approaches
- Other names
- NYD-TSP1TSP1FLJ25709PPP1R148CILD38Testis-specific protein 1Testis-specific protein NYD-TSP1testis secretory sperm-binding protein Li 232mspermatogenic zip 1protein phosphatase 1 regulatory subunit 148
02
Biological functions
Spermatogenesiscell proliferationcell differentiationregulation of tissue homeostasisapoptosismitogen-activated protein kinase (MAPK) signaling
03
Disease associations
Cancerinfertility (male)tumorigenesis
04
Safety considerations
Potential risk of germ cell apoptosis and male infertility due to aberrant expression or upregulationinvolvement in cell proliferation linked to oncogenesis
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