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Target intelligence / Profile preview
Spermine oxidase
- Molecular classification
- Enzyme, Flavoprotein, Oxidase
01
Overview
Spermine oxidase (SMOX) is a flavoprotein enzyme that plays a central role in polyamine catabolism. It catalyzes the direct oxidation of spermine to spermidine, producing hydrogen peroxide (H₂O₂) and 3-aminopropanal as byproducts. This reaction is FAD-dependent. SMOX regulates intracellular concentrations of spermine and spermidine, which are essential for cell growth, differentiation, and survival. By producing H₂O₂ as a byproduct, SMOX contributes to cellular oxidative stress responses. Altered SMOX activity has been implicated in various diseases, including cancer progression and liver function abnormalities.
- Other names
- PAOh1/SMOAtPAO1AtPAO4
02
Mechanism of action
Catalyzes the oxidation of spermine to spermidine, producing hydrogen peroxide and 3-aminopropanal.
03
Biological functions
Polyamine catabolismRegulation of polyamine homeostasisCell growth regulationCell differentiation regulationOxidative stress response
04
Disease associations
Cancer progressionLiver function abnormalitiesOxidative stress-related pathologies
05
Safety considerations
Increased oxidative stress due to H₂O₂ production
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