Target intelligence / Profile preview

Sphingosine 1-phosphate (S1P)

Target: S1P
Molecular classification: Lipid mediator, Lysosphingolipid, Signaling molecule

Overview

Sphingosine 1-phosphate (S1P) is a bioactive signaling sphingolipid that acts as a potent lipid mediator involved in regulating diverse cellular processes such as cell growth, survival, migration, adhesion, and immune cell trafficking. It exerts its effects primarily through five G protein-coupled receptors (S1PR1-5).

Other names: Sphingosine-1-phosphateS1P

Mechanism of action

S1P receptor modulator

Biological functions

Cell growthCell survivalCell migrationCell adhesionImmune cell traffickingVascular developmentEndothelial barrier integrityNeurogenesis

Disease associations

Autoimmune disordersCardiovascular diseasesCancerFibrosisInflammation

Interacting drugs

Fingolimod

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