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Target intelligence / Profile preview
Sphingosine-1-phosphate lyase 1 (SGPL1)
- Target
- SGPL1
- Molecular classification
- Enzyme, Lyase, Pyridoxal phosphate-dependent enzyme
01
Overview
SGPL1 is a pyridoxal phosphate-dependent enzyme that catalyzes the irreversible cleavage of sphingosine-1-phosphate (S1P), a bioactive lipid mediator, into a long-chain fatty aldehyde and phosphoethanolamine. It is the final enzyme in the sphingolipid degradative pathway and serves as the sole exit point for sphingolipid metabolism. SGPL1 plays a crucial role in regulating inflammation, neuronal autophagy, lipid homeostasis, and apoptosis.
- Other names
- S1PLSPLSP-lyase 1hSPLsphingosine-1-phosphate aldolaseKIAA1252
02
Mechanism of action
SGPL1 catalyzes the irreversible cleavage of sphingosine-1-phosphate (S1P) into a long-chain fatty aldehyde and phosphoethanolamine, thus regulating S1P levels and influencing downstream signaling pathways.
03
Biological functions
Regulation of pro-inflammatory responsesNeutrophil traffickingModulation of neuronal autophagyLipid homeostasisCholesterol homeostasisCeramide productionApoptosisFatty acid metabolic processesSphingolipid metabolism
04
Disease associations
Primary adrenal insufficiencyNephrotic syndromeInflammationNeurodegenerative disease
05
Safety considerations
Inhibition of SGPL1 leads to S1P accumulation with broad effects on immune function, metabolism, apoptosis, and neural health.
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