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Target intelligence / Profile preview
Sphingosine 1-phosphate Receptor (S1PR)
- Target
- S1PR
- Molecular classification
- G protein-coupled receptor
01
Overview
Sphingosine 1-phosphate receptors (S1PRs) are a family of G protein-coupled receptors (GPCRs) that mediate the effects of the bioactive lipid sphingosine-1-phosphate (S1P). There are five known subtypes: S1PR1, S1PR2, S1PR3, S1PR4, and S1PR5. These receptors play crucial roles in regulating cell proliferation, migration, angiogenesis, immune cell trafficking, cytoskeleton organization, and mitogenesis. Modulators targeting these receptors are used for autoimmune diseases such as relapsing-remitting multiple sclerosis.
- Other names
- S1P receptorS1PR1S1PR2S1PR3S1PR4S1PR5
02
Mechanism of action
Modulators act as functional antagonists after initial agonist-induced internalization on lymphocytes, reducing circulating immune cells.
03
Biological functions
Cell proliferationCell migrationAngiogenesisImmune cell traffickingCytoskeleton organizationMitogenesisVascular developmentCardiogenesisNeurogenesisLimb developmentSignal transduction
04
Disease associations
Autoimmune diseasesMultiple SclerosisVascular dysfunctionsInflammation
05
Interacting drugs
Fingolimod/FTY720
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