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Target intelligence / Profile preview
Sphingosine-1-phosphate receptor 1 (S1P1)
- Target
- S1P1
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor, Sphingosine-1-phosphate receptor
01
Overview
Sphingosine-1-phosphate receptor 1 (S1P1) is a G protein-coupled receptor that binds sphingosine 1-phosphate (S1P). It plays a crucial role in vascular maturation, barrier function, and immune cell trafficking. S1P1 is highly expressed on endothelial cells and lymphocytes. Its modulation is a validated therapeutic strategy for autoimmune diseases like multiple sclerosis.
- Other names
- S1PR1EDG1EDG-1Endothelial differentiation gene-1
02
Mechanism of action
Sphingosine 1-phosphate receptor modulators bind to S1PR1, leading to receptor internalization on lymphocytes and preventing lymphocyte egress from lymph nodes, thereby reducing circulating immune cells.
03
Biological functions
Vascular maturationBarrier functionImmune cell traffickingAnti-inflammatory effectsCell proliferationAngiogenesisMigrationCytoskeleton organizationEndothelial chemotaxisSignal transduction
04
Disease associations
Autoimmune diseasesMultiple sclerosisInflammation
05
Interacting drugs
Fingolimod
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