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Target intelligence / Profile preview
Sphingosine 1-phosphate receptor 3 (S1PR3)
- Target
- S1PR3
- Molecular classification
- G protein-coupled receptor (GPCR), EDG family receptor
01
Overview
Sphingosine 1-phosphate receptor 3 (S1PR3) is a G protein-coupled receptor that binds sphingosine-1-phosphate (S1P). It is involved in regulating cell proliferation, angiogenesis, migration, immune cell trafficking, and cardiovascular function. It plays roles in various diseases including fibrosis, cancer, and autoimmune disorders, making it a therapeutic target.
- Other names
- EDG3S1P receptor 3
02
Mechanism of action
Agonist or antagonist binding modulates downstream signaling pathways via Gi/o, Gq/11, and G12/13 G proteins, affecting cellular processes like proliferation, migration, and immune cell trafficking.
03
Biological functions
Cell proliferationAngiogenesisMigrationCytoskeleton organizationEndothelial cell chemotaxisImmune cell traffickingVascular tone regulationVascular permeability regulation
04
Disease associations
Cardiovascular diseaseFibrosisEndometriosisCancerAutoimmune diseases
05
Interacting drugs
Sphingosine 1-phosphate (S1P)
2 more in the full profile.
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