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Target intelligence / Profile preview
Sphingosine-1-phosphate receptor 4 (S1PR4)
- Target
- S1PR4
- Molecular classification
- G protein-coupled receptor, GPCR, Endothelial Differentiation Gene (EDG) family
01
Overview
Sphingosine-1-phosphate receptor 4 (S1PR4) is a G protein-coupled receptor that binds the lipid signaling molecule sphingosine-1-phosphate (S1P). It is primarily expressed on hematopoietic and lymphoid tissues, particularly immune cells like neutrophils and dendritic cells. S1PR4 plays a role in both innate and adaptive immunity, influencing cell proliferation, angiogenesis, migration, cytoskeleton organization, and immune cell trafficking. It couples primarily with Gi and G12/13 proteins, activating Rho kinase and influencing cytoskeletal rearrangement. Its selective expression on immune cells makes it a potential target for modulating immune responses, especially in autoimmune or inflammatory diseases.
- Other names
- EDG6Sphingosine 1-phosphate receptor 4
02
Mechanism of action
Signals through Gi/G12/13 proteins; Modulates Rho kinase activity; Influences PTEN/Akt pathway
03
Biological functions
Cell proliferationAngiogenesisMigrationCytoskeleton organizationImmune cell traffickingImmune modulationSignal transductionApoptosisMetabolismAutophagy
04
Disease associations
Autoimmune diseasesInflammatory diseases
05
Safety considerations
Potential for immune dysregulation
06
Interacting drugs
Sphingosine-1-phosphate (S1P)
2 more in the full profile.
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