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Target intelligence / Profile preview
Sphingosine 1-phosphate receptor subtype 3 (S1PR3)
- Target
- S1PR3
- Molecular classification
- G protein-coupled receptor, GPCR, Class A GPCR, Receptor
01
Overview
Sphingosine 1-phosphate receptor subtype 3 (S1PR3) is a G protein-coupled receptor (GPCR) that binds the bioactive lipid sphingosine-1-phosphate (S1P). It plays a crucial role in regulating angiogenesis, immune responses, and hematopoietic stem cell fate. S1PR3 is implicated in various diseases including sepsis, acute myeloid leukemia, and intervertebral disc degeneration. Upon binding S1P, S1PR3 activates multiple downstream signaling pathways via coupling to different G proteins, influencing diverse cellular responses including inflammation, cell survival, migration, and differentiation. Its expression is inducible in hematopoietic stem cells upon exposure to pro-inflammatory cytokines like TNFα.
02
Mechanism of action
Modulation of S1PR3 signaling via agonists or antagonists impacts diverse cellular functions including immune cell trafficking, inflammation, and cell fate decisions.
03
Biological functions
Angiogenesis regulationImmune system modulationLeukocyte adhesion and rollingReactive oxygen species generationInflammatory pathway activationHematopoietic stem cell differentiationCell survivalCell migrationCell differentiationSignal transduction
04
Disease associations
SepsisAcute myeloid leukemia (AML)Intervertebral disc degenerationInflammationInfection
05
Biomarkers
S1PR3 expression level in AML cells as a biomarker for less functional leukemia stem cells
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