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Target intelligence / Profile preview
Sphingosine 1-Phosphate Receptor Subtype 4 (S1PR4)
- Target
- S1PR4
- Molecular classification
- G protein-coupled receptor (GPCR), Endothelial Differentiation Gene (EDG) family, Receptor
01
Overview
Sphingosine 1-Phosphate Receptor Subtype 4 (S1PR4) is a G protein-coupled receptor that binds sphingosine 1-phosphate (S1P). It is primarily expressed in immune cells and brain endothelial cells. S1PR4 plays a role in immune cell trafficking, activation, and vascular permeability. It has been implicated in diseases such as asthma, cancer, and neurological disorders involving blood-brain barrier dysfunction, making it a potential therapeutic target.
- Other names
- S1P4EDG6
02
Mechanism of action
Agonists bind to S1PR4, activating G proteins (Gαi/Gα12/13) and downstream signaling pathways such as MAPK/JNK and RhoA/ROCK, influencing immune cell function and vascular permeability.
03
Biological functions
Immune cell traffickingImmune cell activationLymphocyte migrationActin dynamics regulationVascular permeability regulationSignal transduction
04
Disease associations
AsthmaAirway inflammationCancerAutoimmune diseasesNeuroinflammatory disordersBlood-brain barrier dysfunction
05
Safety considerations
Potential for off-target effects due to GPCR signaling complexity.Immunosuppression in certain contexts, requiring careful monitoring.Effects on vascular function need thorough evaluation.
06
Interacting drugs
Sphingosine 1-phosphate (S1P)
1 more in the full profile.
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