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Target intelligence / Profile preview
Sphingosine 1-phosphate receptor subtype 5 (S1PR5)
- Target
- S1PR5
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
Sphingosine 1-phosphate receptor subtype 5 (S1PR5) is a G protein-coupled receptor (GPCR) that binds the bioactive lipid sphingosine-1-phosphate (S1P). It plays a critical role in regulating T cell trafficking, particularly influencing the infiltration and emigration of T cells from peripheral organs and is involved in innate lymphoid cell development and NK cell trafficking. It is also a potential therapeutic target for neurodegenerative and demyelinating diseases by supporting oligodendrocyte function and myelination, and in cancer by influencing tumor growth and metastasis.
- Other names
- EDG8
02
Mechanism of action
Agonists or antagonists modulate S1PR5-mediated signaling pathways, influencing immune cell trafficking, oligodendrocyte function, and tumor growth.
03
Biological functions
Immune system regulationT cell traffickingNatural killer cell traffickingOligodendrocyte functionSignal transduction
04
Disease associations
CancerNeurodegenerative diseaseDemyelinating disease
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