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Target intelligence / Profile preview
Sphingosine kinase 1 (SphK1)
- Target
- SphK1
- Molecular classification
- Enzyme, Lipid kinase
01
Overview
Sphingosine kinase 1 (SphK1) is a lipid kinase enzyme that catalyzes the phosphorylation of sphingosine to produce sphingosine-1-phosphate (S1P), a potent bioactive lipid mediator. It plays a critical role in regulating cell survival, proliferation, differentiation, migration, and immune function. SphK1 is implicated in various diseases, including cancer, inflammation, and metabolic disorders, making it a potential therapeutic target. Selective inhibitors like SKI-I have shown promise in preclinical studies.
- Other names
- SPHK1SKI
02
Mechanism of action
Inhibition of SphK1, leading to decreased S1P production and increased ceramide/sphingosine levels.
03
Biological functions
Cell survivalCell proliferationCell migrationInflammationAngiogenesisApoptosis regulationImmune responseSphingolipid metabolismSignal transduction
04
Disease associations
CancerMetabolic diseaseChronic inflammationDiabetes/obesity-related complications
05
Interacting drugs
SKI-I
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