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Target intelligence / Profile preview
Sphingosine kinase 2 (SK2)
- Target
- SK2
- Molecular classification
- Enzyme, Kinase, Lipid kinase
01
Overview
Sphingosine kinase 2 (SK2) is an enzyme that catalyzes the phosphorylation of sphingosine to produce sphingosine 1-phosphate (S1P), a bioactive lipid mediator involved in diverse cellular processes including cell migration, proliferation, apoptosis, angiogenesis, and tumorigenesis. SK2 is predominantly localized in the nucleus but can be exported to the cytoplasm. It is regulated by phosphorylation at specific residues. SK2 is implicated in several diseases, including cancer and COPD.
- Other names
- SPHK2SphK2
02
Mechanism of action
Inhibition of Sphingosine kinase 2 activity
03
Biological functions
Phosphorylation of sphingosineCell migrationCell proliferationApoptosisAngiogenesisTumorigenesisRegulation of transcriptionTelomere maintenanceMitochondrial respirationActin rearrangement
04
Disease associations
CancerChronic Obstructive Pulmonary Disease (COPD)Mast cell disorders
05
Safety considerations
Potential for off-target effects due to broad role of S1P signalingContradictory roles across different cancer types
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