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Target intelligence / Profile preview
Sphingosine phosphate 1 receptor (S1PR1)
- Target
- S1PR1
- Molecular classification
- G protein-coupled receptor, GPCR
01
Overview
The sphingosine phosphate 1 receptor (S1PR1) is a G protein-coupled receptor that binds sphingosine-1-phosphate (S1P). It plays a crucial role in immune cell trafficking, vascular development, and angiogenesis. S1PR1 is a therapeutic target for autoimmune diseases like multiple sclerosis, where its modulation leads to lymphocyte sequestration in lymph nodes, reducing circulating lymphocytes available to enter the central nervous system.
- Other names
- Endothelial differentiation gene 1EDG-1SIPR1
02
Mechanism of action
Modulation/antagonism of S1PR1 leading to lymphocyte sequestration in lymph nodes.
03
Biological functions
Cell proliferationAngiogenesisCell migrationCytoskeleton organizationEndothelial cell chemotaxisImmune cell traffickingLymphocyte maturationVascular maturationMitogenesisSignal transduction
04
Disease associations
Multiple sclerosisAutoimmune diseasesCancerInflammation
05
Interacting drugs
Fingolimod
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