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Target intelligence / Profile preview
Sphingosine Phosphate Receptor 1 (S1PR1)
- Target
- S1PR1
- Molecular classification
- G protein-coupled receptor
01
Overview
Sphingosine phosphate receptor 1 (S1PR1) is a G protein-coupled receptor that binds sphingosine-1-phosphate (S1P). It plays a crucial role in immune cell trafficking, vascular regulation, and cellular processes like proliferation and migration. S1PR1 is a validated therapeutic target for autoimmune diseases, particularly multiple sclerosis, due to its role in controlling lymphocyte egress from lymphoid tissues.
- Other names
- Sphingosine-1-phosphate receptor 1S1P receptor 1
02
Mechanism of action
Binding to lymphocyte-expressed S1PR1 leads to internalization and functional antagonism, trapping lymphocytes within lymph nodes and preventing their egress into circulation.
03
Biological functions
Immune cell traffickingVascular regulationCell proliferationCell migrationCytoskeleton organizationChemotaxis of endothelial cellsMitogenesisImmune modulation
04
Disease associations
Autoimmune diseasesMultiple sclerosisConditions involving aberrant angiogenesisConditions involving vascular leakage
05
Interacting drugs
Drugs modulating S1PR1 for multiple sclerosis treatment
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