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Target intelligence / Profile preview
Spike Glycoprotein (MERS-CoV) (S protein)
- Target
- S protein
- Molecular classification
- Viral protein, Class I fusion protein, Glycoprotein
01
Overview
The spike glycoprotein (S protein) of Middle East respiratory syndrome coronavirus (MERS-CoV) is a large, trimeric, class I fusion protein that protrudes from the viral envelope. It is essential for viral entry into host cells and serves as the main target for neutralizing antibodies and therapeutic interventions. The S protein consists of two functional subunits: S1 (responsible for receptor binding to DPP4) and S2 (mediates membrane fusion).
- Other names
- MERS-CoV Spike proteinS glycoproteinMERS-CoV S protein
02
Mechanism of action
Inhibition of receptor binding; disruption of membrane fusion
03
Biological functions
Host cell attachmentMembrane fusionReceptor binding (DPP4/CD26)Viral entry
04
Disease associations
InfectionMiddle East Respiratory Syndrome (MERS)
05
Safety considerations
Potential for antibody-dependent enhancement (ADE) of infectionEliciting a durable and broadly protective immune response
06
Interacting drugs
Monoclonal antibodies targeting RBD/S1
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