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Target intelligence / Profile preview
Spike Glycoprotein of Middle East Respiratory Syndrome Coronavirus (MERS-CoV Spike)
- Target
- MERS-CoV Spike
- Molecular classification
- Glycoprotein, Viral structural protein, Class I fusion protein
01
Overview
The spike glycoprotein (S protein) is a major structural component of the MERS-CoV virion, forming large protruding spikes on the virus surface. It is essential for viral entry into host cells and determines host specificity and infectivity. The S protein is a homotrimeric class I fusion protein, with each monomer composed of two subunits: S1 (receptor binding) and S2 (membrane fusion). The S1 subunit contains the receptor-binding domain (RBD) which specifically binds to dipeptidyl peptidase 4 (DPP4). The S protein undergoes proteolytic cleavage at S1/S2 and S2' sites. Mutations in the RBD can affect DPP4 affinity and antibody neutralization sensitivity. It is a major therapeutic target and diagnostic antigen.
- Other names
- MERS-CoV S proteinSpike proteinS glycoprotein
02
Mechanism of action
Inhibition of receptor binding and/or membrane fusion
03
Biological functions
Receptor bindingMembrane fusionViral entryAttachment factorImmune evasion
04
Disease associations
InfectionMiddle East Respiratory Syndrome (MERS)
05
Safety considerations
Potential for antibody-dependent enhancement (ADE)Viral escape mutantsOff-target effects of entry inhibitors
06
Interacting drugs
Entry inhibitors
1 more in the full profile.
07
Biomarkers
Antibody levels against Spike proteinRBD mutations
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