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Target intelligence / Profile preview
Spike glycoprotein of SARS-CoV-2 (Ancestral Strain) (S protein)
- Target
- S protein
- Molecular classification
- Viral protein, Glycoprotein, Fusion protein, Class I fusion protein
01
Overview
The spike glycoprotein (S protein) of SARS-CoV-2 is a large, trimeric, class I fusion protein found on the surface of the virus. It is essential for viral entry into host cells and is the primary target for neutralizing antibodies generated by infection or vaccination. The ancestral strain refers to the original Wuhan-Hu-1 sequence identified at the start of the COVID-19 pandemic. It mediates attachment to host cell receptors via its RBD. After binding ACE2, undergoes conformational changes that allow membrane fusion through its S2 subunit. Most first-generation COVID vaccines are based on either full-length or modified versions of this ancestral spike sequence.
- Other names
- SARS-CoV-2 Spike proteinSpike glycoproteinS protein (ancestral strain)Wuhan-Hu-1 Spike protein
02
Mechanism of action
Blockade of receptor binding (ACE2) and/or inhibition of membrane fusion
03
Biological functions
Viral entryReceptor binding (ACE2)Membrane fusionImmunogenicityTarget of neutralizing antibodies
04
Disease associations
InfectionCOVID-19Viral pathogenesis
05
Safety considerations
Antibody-dependent enhancement (ADE) (theoretical)Reduced efficacy against variants with spike mutationsPotential for immune escape
06
Interacting drugs
Monoclonal antibodies (e.g., Bamlanivimab, Etesevimab, Casirivimab, Imdevimab)
1 more in the full profile.
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