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Target intelligence / Profile preview
Spike glycoprotein of SARS-CoV-2 (D614G variant)
- Molecular classification
- Viral envelope surface glycoprotein
01
Overview
The spike glycoprotein (S protein) is a trimeric, highly glycosylated surface protein of SARS-CoV-2 that mediates viral entry into host cells. The D614G variant refers to a specific mutation in which the amino acid aspartic acid (D) at position 614 is replaced by glycine (G). This mutation increases infectivity and transmissibility, becoming globally dominant during the COVID-19 pandemic.
- Other names
- SARS-CoV-2 Spike protein (D614G)Spike glycoprotein (D614G)S protein (D614G)D614G Spike
02
Mechanism of action
Neutralizing antibodies bind to the spike protein and prevent its interaction with ACE2, thus blocking viral entry.
03
Biological functions
Viral entryACE2 receptor bindingMembrane fusionImmune evasion
04
Disease associations
InfectionCOVID-19
05
Safety considerations
Potential for antibody-dependent enhancement (ADE)Emergence of new variants with altered antigenicity
06
Interacting drugs
Neutralizing antibodies
1 more in the full profile.
07
Biomarkers
Spike protein levels in infected individuals (viral load)Antibody titers against Spike protein post-vaccination or infection
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