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Target intelligence / Profile preview
Spike Glycoprotein S (SARS-CoV-2)
- Molecular classification
- Glycoprotein, Viral Fusion Protein, Class I fusion protein
01
Overview
The spike glycoprotein (S protein) of SARS-CoV-2 is a large, trimeric class I fusion protein that protrudes from the viral surface and is essential for mediating viral entry into host cells. It binds to the ACE2 receptor on human cells, facilitating membrane fusion and infection. The S protein is heavily glycosylated, forming a "glycan shield" that aids in immune evasion. It is a primary target for neutralizing antibodies and the basis for most COVID-19 vaccines.
- Other names
- Spike ProteinE2
02
Mechanism of action
Neutralizing antibody binding, inhibition of viral entry
03
Biological functions
Receptor bindingViral entryMembrane fusionImmune evasion
04
Disease associations
Infection
05
Safety considerations
Potential for triggering signaling cascades independent of viral entry, leading to pulmonary vascular remodeling or hypertension.
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