Target intelligence / Profile preview

Spike Glycoprotein S1 Subunit (S1)

Target: S1
Molecular classification: Glycoprotein, Viral protein

Overview

The spike glycoprotein S1 subunit is a critical component of the coronavirus spike (S) protein, responsible for mediating viral entry into host cells by binding to host cell receptors like ACE2. It is a major target for neutralizing antibodies and plays a role in modulating immune responses during infection, potentially contributing to cytokine storm.

Other names: CoV_S1E2Peplomer Protein

Mechanism of action

Neutralizing antibody binding prevents interaction with ACE2

Biological functions

Receptor bindingHost cell attachmentImmune response elicitation

Disease associations

InfectionCOVID-19 pathogenesis

Safety considerations

Potential for cytokine storm induction

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