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Spike Protein (SARS-CoV-2) (S protein)

Target: S protein
Molecular classification: Glycoprotein, Type I transmembrane protein

Overview

The spike protein (S protein) of SARS-CoV-2 is a large, trimeric glycoprotein that protrudes from the viral surface and is essential for mediating viral entry into host cells. It binds specifically to angiotensin-converting enzyme 2 (ACE2) receptors on human cells, triggering conformational changes that lead to fusion between the viral envelope and the host cell membrane, allowing viral RNA entry.

Other names: SARS-CoV-2 SpikeS proteinSpike glycoprotein

Mechanism of action

Binding to ACE2 receptor, triggering conformational change and membrane fusion

Biological functions

Receptor bindingMembrane fusionViral entry into host cells

Disease associations

Infection

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